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asarum_heterotropoides_f._schmidt

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asarum_heterotropoides_f._schmidt [2015/06/30 17:09]
andreas
asarum_heterotropoides_f._schmidt [2015/06/30 17:26]
andreas
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 The dried rhizome and roots of Asiasarum heterotropoides are used together with the very similar [[asarum_sieboldii_miq|Asiasarum sieboldii]] roots as Asiasarum root or Asarum root, Asiasari radix. The drug (var.heterotropoides) yields a volatile oil (1.6-1.9%) with methyl eugenol, safrole, and eucarvon. The roots of var. mandshuricum contain more oil (2.2-5.5%), with methyl eugenol (47%) as main constituent, further safrole, elemicin and eucarvone, some alpha-pinene and aliphatic amides (pellitorine e.g.). Higenamine is stated as characteristic for the Asiasarum heterotropoides. \\ The dried rhizome and roots of Asiasarum heterotropoides are used together with the very similar [[asarum_sieboldii_miq|Asiasarum sieboldii]] roots as Asiasarum root or Asarum root, Asiasari radix. The drug (var.heterotropoides) yields a volatile oil (1.6-1.9%) with methyl eugenol, safrole, and eucarvon. The roots of var. mandshuricum contain more oil (2.2-5.5%), with methyl eugenol (47%) as main constituent, further safrole, elemicin and eucarvone, some alpha-pinene and aliphatic amides (pellitorine e.g.). Higenamine is stated as characteristic for the Asiasarum heterotropoides. \\
 [Hagers Handbuch der Pharmazeutischen Praxis, Springer 2010]  [Hagers Handbuch der Pharmazeutischen Praxis, Springer 2010] 
-Fujita Y, Bot.Mag.Tokyo, 79, (1966), 783-790;  
-Yasuda I, Takeya K, Itokawa H, Chem.Pharm.Bull., 29, (1981), 564-6;  
-Liu L, Li Y, Chem CC Chou TC, Wang HH, cit. CA 96, 126043  
  
 Two lignanes, asarinin and xanthoxylol, were isolated and exhidited  antitumor effects in mice. \\ Two lignanes, asarinin and xanthoxylol, were isolated and exhidited  antitumor effects in mice. \\
-[Takasaki M, Konoshima T, Yasuda I, Hamano T, Tokuda H, Biol.Pharm.Bull., 20(7), (1997), 776-780]+[Takasaki M, Konoshima T, Yasuda I, Hamano T, Tokuda H, Biol.Pharm.Bull., 20(7), 1997, 776-780]
  
 +Root extracts (80% EtOH, LC) of A. heterotropoides contained tetrahydrofuran lignans, aristolactams, an aristolochic acid derivative, three flavanones, two monoterpenes, and four phenolics. Among the 22 tested compounds, two (7-methoxyaristololactam IV, and (7α,7'β,8α,8'α)-3,4-methylenedioxy-3',4'-dihydroxy-7,9':7',9-diepoxy-lignane) induced the downregulation of NO production, FOXP3 expression, and HIF-1α transcriptional activity. \\
 +[Bioactive Compounds from the Roots of Asiasarum heterotropoides., Lee, J., Lee, Y.J., Oh, S.M., Yi, J.M., Kim, N.S., Bang, O.S., Molecules, 19(1), 2013, 122-138] [[http://www.mdpi.com/1420-3049/19/1/122/htm]] 
 +
 +pictures: [[http://www.asianflora.com/Aristolochiaceae/Asarum-heterotropoides.htm]]
asarum_heterotropoides_f._schmidt.txt · Zuletzt geändert: 2015/07/02 07:56 von andreas